GeneIII® L-Ergothioneine
+ Milk Thistle Extract
Invested in
Clinical Studies
Customers
Worldwide
Peer-Reviewed
Studies on EGT
International
Patents
Frequently Asked Questions
Uncompromising Quality
At GeneIII, we hold ourselves to the highest standards in research, quality, and safety.
See What Sets
GeneIII Apart
How Benefits Build
Over Time
Two Ingredients.
One Focused Formula.
Milk Thistle Extract
L-Ergothioneine
Powerful Antioxidant
A rare antioxidant with a dedicated transporter in the human body. EGT is actively taken up and retained in tissues including the liver, where it helps protect cells from oxidative stress.*
L-Ergothioneine
Liver Health Support
Concentrated 20:1 milk thistle seed extract, made from 1,600 mg of starting seed and standardized for silymarin to support healthy liver function and antioxidant defenses.*
Milk Thistle Extract
30 mg of ultra-pure L-Ergothioneine for everyday energy, cognitive, and cellular support, plus concentrated 20:1 Milk Thistle Extract for added liver support.*
- Healthy liver function & enzyme levels*
- Deeper sleep*
- Natural energy*
Who Is This For?
Made for people who want the everyday benefits of L-Ergothioneine, with extra support for liver health.
A good fit if you:
- Want to support natural energy, cognitive health, and healthy aging*
- Are looking for added liver support in the same daily capsule*
- Prefer consistent, long-term support over an occasional “cleanse”
Key Ingredients
30 mg L-Ergothioneine: A rare antioxidant that supports natural energy, cognitive health, cellular protection, and liver health.
80 mg Milk Thistle Extract: A concentrated 20:1 Milk Thistle Seed Extract, standardized to ≥80% silymarin, for added liver support.
Together, they support the liver’s natural antioxidant defenses against everyday cellular stress.*
Other ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Magnesium Stearate.
How to Take
Take 1-2 capsules daily, with or without food. Some people prefer taking it in the morning. Consistent daily use is recommended for best results.
What to Expect
Some people may notice improvements in areas like natural energy and sleep quality within the first 4–6 weeks, while many of the benefits of EGT + Milk Thistle are about supporting cellular and liver health behind the scenes over time.*
For best results, we recommend consistent daily use for at least 3 months.
Quality & Testing
Quality is controlled at every step, with rigorous testing to verify purity, identity, and consistency before each batch is released.
✓ Third-party lab tested
✓ Manufactured in a cGMP-compliant facility in the USA
✓ FDA GRAS Notice GRN 001270 for GeneIII® L-Ergothioneine
✓ Vegan - No artificial sweeteners - No artificial preservatives
What is L-Ergothioneine?
L-Ergothioneine (EGT) is a naturally occurring antioxidant that your body can’t make on its own. Yet your body has a specialized transporter, OCTN1, that actively takes up and retains EGT in tissues including the liver, brain, eyes, and kidneys, where it helps protect cells from oxidative stress.*
How does L-Ergothioneine support liver health?
The liver is one of the tissues where EGT naturally accumulates. Through the OCTN1 transporter, the body actively takes up EGT, where it can help support cellular antioxidant defenses against oxidative stress.
Milk thistle adds more targeted botanical support for healthy liver function and the body’s natural detoxification processes.*
What does 20:1 Milk Thistle Extract, standardized to ≥80% silymarin mean?
It means this is much more concentrated than ordinary milk thistle powder.
A 20:1 extract concentrates approximately 20 parts milk thistle seed into 1 part extract— so each serving is made from about 1,600 mg of starting seed.
Standardized to ≥80% silymarin by UV means the extract is made to deliver a consistent, high concentration of milk thistle’s key active compounds, unlike regular milk thistle powder where silymarin levels can vary greatly.
When can I expect to notice results?
Some people may notice improvements in areas like natural energy and sleep quality within the first 4-6 weeks, while many of EGT’s benefits are about supporting cellular health and resilience over time.*
We recommend consistent daily use for at least 3 months.
Is it safe to take every day long term?
This formula is designed for consistent daily use. GeneIII® L-Ergothioneine has undergone safety evaluation and is the subject of FDA GRAS Notice GRN 1270. Milk thistle has also been used for centuries to support liver health and is generally well tolerated.
How will I feel when taking GeneIII® L-Ergothioneine + Milk Thistle Extract?
Everyone’s experience is unique. Some people may notice changes in areas like energy or overall well-being, while liver and cellular support may not produce an obvious day-to-day sensation.*
Can I take it with other supplements or medications?
It can generally be incorporated into an existing supplement routine. If you have a medical condition or are taking any medication, we recommend consulting with your healthcare provider before using GeneIII® L-Ergothioneine + Milk Thistle Extract.
Can I take it while pregnant or breastfeeding?
If you are pregnant or nursing, we recommend consulting with your healthcare provider before using GeneIII® L-Ergothioneine + Milk Thistle Extract.
Are there any known side effects?
In clinical studies lasting 1–3 months, no adverse events were reported with GeneIII® L-Ergothioneine. Milk thistle may occasionally cause mild digestive symptoms such as bloating, nausea, or gas, and allergic reactions are possible in people sensitive to related plants. If you have a sensitive stomach, we recommend taking it after a meal.
What makes this different from other liver supplements?
Most liver supplements start with milk thistle and add more herbs. We start with L-Ergothioneine. Each capsule delivers 30mg of 99.99% pure GeneIII® L-Ergothioneine for potent cellular and antioxidant support, then adds a concentrated 20:1 milk thistle extract for an extra focus on liver health.*
Instead of an occasional “detox” formula, this is designed as daily EGT support with targeted liver support built in.
GeneIII vs Other EGT
EGT vs Other Antioxidants
EGT
Glutathione
CoQ10
Resveratrol
Pulled directly into cells through a dedicated transporter, OCTN1
Concentrates in the brain, liver, eyes & other high-stress tissues
Crosses the blood-brain barrier
Retained in the body for weeks to months
Backed by human clinical studies
Partial
Partial
Unclear
Unclear
EGT vs Other Antioxidants
GeneIII vs Other EGT
In-House Manufacturing
FDA GRAS (GRN No. 1270)
99.99% Pure EGT
30+ International Patents
Investigator-Initiated Clinical Trials
Often ≤99%
Other
Brands
ALT (U/L)
GGT (U/L)
Registered Trial: ChiCTR2400093739
Baseline
After 30 Days
After taking 60 mg/day of GeneIII® for 30 days, participants showed improvements in key liver health markers, including ALT and GGT.*
Liver Health
Energy & Fatigue
Clinical Study Results
-21.0% ↓
-18.2% ↓
Daytime Energy
Physical Wellbeing
Registered Trial: ChiCTR2400093739
Baseline
After 30 Days
After 30 days, participants reported significant improvements in how they felt day to day— from their energy during the day to their overall physical wellbeing.*
Liver Health
Energy & Fatigue
+51.6% ↑
+39.0% ↑
3 Months
6 Months
12 Months
First 30 Days
First 30 Days
EGT begins accumulating in the body with consistent daily use, while milk thistle provides added support for healthy liver function and antioxidant defenses.*
Month 3
Month 6
Month 12+
First 30 Days
3 Months
6 Months
12 Months
First 30 Days
3 Months
With daily use, EGT continues to support natural energy, cognitive health, and healthy aging, while concentrated milk thistle provides ongoing liver support.* This is when we recommend evaluating how you feel overall.
Month 6
Month 12+
First 30 Days
3 Months
6 Months
12 Months
First 30 Days
Month 3
6 Months
By now, the goal is less about a short-term detox and more about maintaining steady antioxidant and liver support as part of your everyday routine.*
Month 12+
First 30 Days
3 Months
6 Months
12 Months
First 30 Days
Month 3
Month 6
12 Months
The real advantage is staying consistent. Your liver faces everyday demands year-round. Continued use provides ongoing EGT support throughout the body, with added milk thistle for long-term liver health and cellular protection.*
Frequently Asked Questions
Uncompromising Quality
At GeneIII, we hold ourselves to the highest standards in research, quality, and safety.
How Benefits Build Over Time
Invested in Clinical Studies
Customers Worldwide
Peer-Reviewed Studies on EGT
International Patents
See What Sets GeneIII® Apart
Added Liver Support
Milk Thistle Extract
Powerful Antioxidant
L-Ergothioneine
Two Ingredients.
One Focused Formula.
Clinical Study Results


30 mg of ultra-pure L-Ergothioneine for everyday energy, cognitive, and cellular support, plus concentrated 20:1 Milk Thistle Extract for added liver support.*
- Healthy liver function & enzyme levels*
- Deeper sleep*
- Natural energy*
Who Is This For?
Made for people who want the everyday benefits of L-Ergothioneine, with extra support for liver health.
A good fit if you:
- Want to support natural energy, cognitive health, and healthy aging*
- Are looking for added liver support in the same daily capsule*
- Prefer consistent, long-term support over an occasional “cleanse”
Key Ingredients
30 mg L-Ergothioneine: A rare antioxidant that supports natural energy, cognitive health, cellular protection, and liver health.
80 mg Milk Thistle Extract: A concentrated 20:1 Milk Thistle Seed Extract, standardized to ≥80% silymarin, for added liver support.
Together, they support the liver’s natural antioxidant defenses against everyday cellular stress.*
Other ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Magnesium Stearate.
How to Take
Take 1-2 capsules daily, with or without food. Some people prefer taking it in the morning. Consistent daily use is recommended for best results.
What to Expect
Some people may notice improvements in areas like natural energy and sleep quality within the first 4–6 weeks, while many of the benefits of EGT + Milk Thistle are about supporting cellular and liver health behind the scenes over time.*
For best results, we recommend consistent daily use for at least 3 months.
Quality & Testing
Quality is controlled at every step, with rigorous testing to verify purity, identity, and consistency before each batch is released.
✓ Third-party lab tested
✓ Manufactured in a cGMP-compliant facility in the USA
✓ FDA GRAS Notice GRN 001270 for GeneIII® L-Ergothioneine
✓ Vegan - No artificial sweeteners - No artificial preservatives
Liver Health
Energy & Fatigue
First 30 Days
3 Months
6 Months
12 Months
First 30 Days
EGT begins accumulating in the body with consistent daily use, while milk thistle provides added support for healthy liver function and antioxidant defenses.*
Month 3
With daily use, EGT continues to support natural energy, cognitive health, and healthy aging, while concentrated milk thistle provides ongoing liver support.*
Month 6
By now, the goal is less about a short-term detox and more about maintaining steady antioxidant and liver support as part of your everyday routine.*
Month 12
The real advantage is staying consistent. Your liver faces everyday demands year-round.
What is L-Ergothioneine?
L-Ergothioneine (EGT) is a naturally occurring antioxidant that your body can’t make on its own. Yet your body has a specialized transporter, OCTN1, that actively takes up and retains EGT in tissues including the liver, brain, eyes, and kidneys, where it helps protect cells from oxidative stress.*
How does L-Ergothioneine support liver health?
The liver is one of the tissues where EGT naturally accumulates. Through the OCTN1 transporter, the body actively takes up EGT, where it can help support cellular antioxidant defenses against oxidative stress.
Milk thistle adds more targeted botanical support for healthy liver function and the body’s natural detoxification processes.*
What does 20:1 Milk Thistle Extract, standardized to ≥80% silymarin mean?
It means this is much more concentrated than ordinary milk thistle powder.
A 20:1 extract concentrates approximately 20 parts milk thistle seed into 1 part extract— so each serving is made from about 1,600 mg of starting seed.
Standardized to ≥80% silymarin by UV means the extract is made to deliver a consistent, high concentration of milk thistle’s key active compounds, unlike regular milk thistle powder where silymarin levels can vary greatly.
When can I expect to notice results?
Some people may notice improvements in areas like natural energy and sleep quality within the first 4-6 weeks, while many of EGT’s benefits are about supporting cellular health and resilience over time.*
We recommend consistent daily use for at least 3 months.
Is it safe to take every day long term?
This formula is designed for consistent daily use. GeneIII® L-Ergothioneine has undergone safety evaluation and is the subject of FDA GRAS Notice GRN 1270. Milk thistle has also been used for centuries to support liver health and is generally well tolerated.
How will I feel when taking GeneIII® L-Ergothioneine + Milk Thistle Extract?
Everyone’s experience is unique. Some people may notice changes in areas like energy or overall well-being, while liver and cellular support may not produce an obvious day-to-day sensation.*
Can I take it with other supplements or medications?
It can generally be incorporated into an existing supplement routine. If you have a medical condition or are taking any medication, we recommend consulting with your healthcare provider before using GeneIII® L-Ergothioneine + Milk Thistle Extract.
Can I take it while pregnant or breastfeeding?
If you are pregnant or nursing, we recommend consulting with your healthcare provider before using GeneIII® L-Ergothioneine + Milk Thistle Extract.
Are there any known side effects?
In clinical studies lasting 1–3 months, no adverse events were reported with GeneIII® L-Ergothioneine. Milk thistle may occasionally cause mild digestive symptoms such as bloating, nausea, or gas, and allergic reactions are possible in people sensitive to related plants. If you have a sensitive stomach, we recommend taking it after a meal.
What makes this different from other liver supplements?
Most liver supplements start with milk thistle and add more herbs. We start with L-Ergothioneine. Each capsule delivers 30mg of 99.99% pure GeneIII® L-Ergothioneine for potent cellular and antioxidant support, then adds a concentrated 20:1 milk thistle extract for an extra focus on liver health.*
Instead of an occasional “detox” formula, this is designed as daily EGT support with targeted liver support built in.
GeneIII vs Other EGT
Pulled directly into cells through a dedicated transporter, OCTN1
Concentrates in the brain, liver, eyes & other high-stress tissues
Crosses the blood-brain barrier
Retained in the body for weeks to months
Backed by human clinical studies
EGT vs. Other Antioxidants
EGT
Glutathione
CoQ10
Resveratrol
Partial
Partial
Unclear
Unclear
EGT vs. Other Antioxidants
GeneIII vs Other EGT
In-House Manufacturing
FDA GRAS (GRN No. 1270)
99.99% Pure EGT
30+ International Patents
Investigator-Initiated Clinical Trials
Brands
Often ≤99%

