Your body treats EGT differently from ordinary antioxidants:
Your body can’t make EGT, yet it has a specialized transporter, OCTN1, that actively seeks it out, carries it into the cells, and concentrates it in crucial areas like the brain, liver, and blood cells.
ERGOTHIONEINE (EGT)
OTHER ANTIOXIDANTS
DEDICATED TRANSPORTER
CELL
$15M+
Invested in Clinical Studies
180K+
Customers Worldwide
100+
Peer-Reviewed Studies on EGT
30+
International Patents
Shop Now
Award-winning clinically studied L-Ergothioneine products.
The Foundation of Healthy Aging.
EGT once cost up to $1 million per kg. We developed the biotechnology to change that.
And the more scientists study it, the more interesting it gets.
EGT levels decline with age. Researchers have also linked EGT status with markers of healthy aging— prompting some scientists to propose it as a potential “longevity vitamin.”
GeneIII® L-Ergothioneine in clinical studies:
Loved By Our Customers
The GeneIII® Difference
01 . In-House Manufacturing
02 . 99.99% Purity
03 . 30+ International Patents
04 . Human Clinical Trials
05 . Scientific Collaborations
Discover
Our Products
Original GeneIII® EGT
GeneIII® EGT
+ Milk Thistle Extract
Ovarian Health
Liver Health
Postpartum Health
Energy & Fatigue
After 30 days, participants reported significant improvements in how they felt day to day— from their energy during the day to their overall physical wellbeing.*
+51.6% ↑
+39.0% ↑
Daytime Energy
Physical Wellbeing
Baseline
After 30 Days
Registered Trial: ChiCTR2400093739
Ovarian Health
Liver Health
Postpartum Health
Energy & Fatigue
After taking 60 mg/day of GeneIII® for 30 days, participants showed improvements in key liver health markers.*
-21.0% ↓
-19.6% ↓
ALT
(U/L)
AST
(U/L)
Baseline
After 30 Days
Registered Trial: ChiCTR2400093739
Ovarian Health
Liver Health
Postpartum Health
Energy & Fatigue
After taking 120 mg/day of GeneIII® for 3 menstrual cycles, participants showed significant improvements in key measures linked to ovarian health.*
+38.0% ↑
+38.0% ↑
AMH
(ng/mL)
E₂
(pmol/L)
Baseline
After 3-cycle
Registered Trial: ChiCTR2500104484
Ovarian Health
Liver Health
Postpartum Health
Energy & Fatigue
In a randomized, double-blind, placebo-controlled trial, postpartum women taking 120 mg/day of GeneIII® for 30 days showed improvements in quality of life, physical fatigue, sleep, and daytime function.*
+35.9% ↑
-27.8% ↓
Quality of Life
(SF-36)
Physical Fatigue
Baseline
After 30 Days
Registered Trial: ChiCTR2500114171
Scientific Research Partner
2026 Consumer Innovation Brand
Natural Ingredients Gold Winner
“I’ve been sleeping through the night much more consistently”
- Julieta R.
“I feel so much clearer and energized in the morning!”
- Michael T.
EGT once cost up to $1 million per kg. We developed the biotechnology to change that.
Your body treats EGT differently from ordinary antioxidants:
Your body can’t make EGT, yet it has a specialized transporter, OCTN1, that actively seeks it out, carries it into the cells, and concentrates it in crucial areas like the brain, liver, and blood cells.
GeneIII® EGT
in Clinical Studies:
The GeneIII® Difference
DEDICATED TRANSPORTER
ERGOTHIONEINE (EGT)
$15M+
Invested in
Clinical Studies
180K+
Customers
Worldwide
100+
Peer-Reviewed Studies on EGT
30+
International Patents
EGT levels decline with age. Researchers have also linked EGT status with markers of healthy aging— prompting some scientists to propose it as a potential “longevity vitamin.”
And the more scientists study it, the more interesting it gets.
Award-winning clinically studied GeneIII® L-Ergothioneine
The Foundation of Healthy Aging.
Shop Now
01 . In-House Manufacturing
02 . 99.99% Purity
03 . 30+ International Patents
04 . Human Clinical Trials
05 . Scientific Collaborations
Learn More About GeneIII
Loved By Our Customers
Discover
Our Products
GeneIII® EGT
+ Milk Thistle Extract
Original GeneIII® EGT
Scientific Research Partner
2026 Consumer Innovation Brand
Natural Ingredients Gold Winner
“I feel so much clearer and energized in the morning!”
- Michael T.
“I’ve been sleeping through the night much more consistently”
- Julieta R.
“I feel so much clearer and energized in the morning!”
- Michael T.
“I’ve been sleeping through the night much more consistently”
- Julieta R.
“I feel so much clearer and energized in the morning!”
- Michael T.
“I feel so much clearer and energized in the morning!”
- Michael T.
“I’ve been sleeping through the night much more consistently”
- Julieta R.
“I feel so much clearer and energized in the morning!”
- Michael T.
“I’ve been sleeping through the night much more consistently”
- Julieta R.
“I feel so much clearer and energized in the morning!”
- Michael T.
Better Aging Starts at the Cellular Level.
Deep, Restorative Sleep
Your body does its deepest repair at night. L-Ergothioneine is transported into cells involved in recovery and stress response, supporting more restful, uninterrupted sleep. In our 30-day clinical trial, 51% of participants reported fewer sleep disturbances.*
Improved Energy Levels
Energy without the crash. By protecting cells from everyday oxidative stress, L-Ergothioneine supports your mitochondria, the engines of cellular energy, helping you sustain steady focus and vitality throughout the day, no stimulants required.*
Cognitive Performance
Clarity starts at the cellular level. L-Ergothioneine accumulates in the brain through OCTN1, your body's dedicated transporter, where it helps support cognitive function, focus, and long-term brain health for years to come.*
Energy, Focus & Balance - Every Day
Natural Ingredients Gold Winner
2026 Consumer Innovation Brand
Scientific Research Partner
Professor Barry Halliwell and GeneIII Co-Founder Wei Ding
The GeneIII Difference
From Lab to Capsule: We Make It
Our L-Ergothioneine isn’t sourced. It’s produced through our own fermentation process in-house.
End-to-end control means every batch meets the same standard: Clean, consistent, and fully traceable.
99.99% Purity: The Gold Standard
We carefully isolate and purify the L-Ergothioneine to an exceptional level of purity: 99.99%, which is the highest purity on the market.
At first glance, 98% or 99% may seem similar, but that difference means up to 100× more impurities. Higher purity means a cleaner, more consistent ingredient.
30+ International Patents
Our work is protected by over 30 international patents.
It reflects years of research, development, and a commitment to advancing how L-Ergothioneine is produced.
Human Clinical Trials
We sponsor Investigator-Initiated Trials (IITs)—rigorous, independent clinical studies designed to validate the efficacy of our specific ingredient.
Our commitment to this level of proof ensures that every capsule you take is backed by direct evidence of its safety and efficacy.
Clinical Study Results
Energy & Fatigue
Participants reported measurable improvements after 30 days of GeneIII L-Ergothioneine supplementation:
- 39% improvement in overall physical function, including reduced fatigue and improved recovery*
- 51.56% improvement in daytime energy levels*
- Improvements in sleep quality and how participants felt the next day*
Ovarian Health
In a 3-cycle clinical observation, participants showed measurable changes in markers associated with ovarian function:
- AMH levels improved (from 1.79 to 2.47 ng/mL after 3 cycles)*
- Significant improvements in cycle regularity and menstrual comfort*
- Reductions in symptoms commonly associated with hormonal imbalance*
Liver Health
In a 30-day clinical trial, participants taking 60mg of GeneIII L-Ergothioneine daily showed:
- Around 20% reduction in AST levels associated with liver stress*
- Around 21% reduction in ALT levels*
- 18% reduction in GGT levels after 30 days*
- Improvements in physical recovery and fatigue*
Postpartum Health
A placebo-controlled human clinical trial found that postpartum participants taking GeneIII L-Ergothioneine for 30 days experienced significant improvements compared to placebo
- 35.94% improvement in overall quality of life (SF-36)*
- 37.43% increase in daily vitality*
- 27.78% reduction in physical fatigue*
*Based on findings from registered human clinical studies and observational research on GeneIII L-Ergothioneine. Results may vary.
Why Supplementation Matters
Your body naturally stores L-Ergothioneine in vital tissues like the liver, eyes, and brain, but modern diets provide only trace amounts since its richest sources, mainly mushrooms, are rarely eaten. Supplementation is a reliable way to support healthy cellular levels of this rare nutrient for lasting energy, resilience, and healthy aging.
Each GeneIII capsule delivers 30 mg of pure L-Ergothioneine, which is comparable to the amount naturally found in approximately 300–500 g of reishi mushrooms.
Customer Reviews
"I was honestly surprised at how much clearer my mind felt after taking this... I noticed way less brain fog and better focus after taking this. So happy I added this to my routine!"
"I was honestly surprised at how much clearer my mind felt after taking this... I noticed way less brain fog and better focus after taking this. So happy I added this to my routine!"
"After taking this product for several weeks, I noticed a difference in focus and mental clarity. I felt sharper and also much more energized the next day after taking this."
"I bought this for my mom. She already takes CoQ10, and I was hoping this would enhance the mental clarity it provides. It has done a great job. She really feels like it is helping her remember more and that she is finally getting a good night's sleep, not waking up 7 or 8 times during the night."
Our Products
Frequently Asked Questions
What is L-Ergothioneine?
L-Ergothioneine (L-EGT) is a rare amino acid and powerful antioxidant naturally found in mushrooms. Unlike most antioxidants, your body has a dedicated transporter called OCTN1 specifically designed to absorb and retain it in areas with high oxidative stress, including the brain, liver, eyes, and skin.
Research suggests L-Ergothioneine may play an important role in supporting cellular health, healthy aging, cognitive function, and resilience against everyday oxidative stress.
Can't I just get L-Ergothioneine from food?
You can, but typically only in very small amounts.
L-Ergothioneine is primarily found in certain mushrooms, though levels vary significantly depending on species, growing conditions, storage, and preparation. To reach the amount found in a single GeneIII capsule, you may need to consume several hundred grams of mushrooms daily.
GeneIII uses a patented fermentation-based process to produce highly pure L-Ergothioneine with consistent potency and quality in every capsule.
How do I take GeneIII L-EGT?
Take 1-2 capsules daily, with or without food.
L-Ergothioneine is designed to build up in the body over time through the OCTN1 transporter system. Consistency matters more than timing, so we recommend taking it daily as part of your long-term wellness routine.
Why should I take GeneIII L-EGT?
Modern life exposes our cells to constant oxidative stress from aging, poor sleep, environmental factors, and everyday metabolism.
L-Ergothioneine helps support the body’s natural defense systems at the cellular level. GeneIII L-EGT is designed to support healthy aging, cognitive health, energy production, sleep quality, and overall cellular resilience.
What makes GeneIII different is our commitment to purity, research, and quality. We produce our own L-Ergothioneine using patented biotechnology and achieve 99.99% purity, backed by rigorous testing and registered human clinical research.
When will I feel something?
Everyone’s experience is different. Some people report noticing improvements in areas like energy, sleep quality, or overall well-being within a few weeks of consistent use, while others may notice more gradual changes over time.
Because L-Ergothioneine works at the cellular level, it is best thought of as a long-term investment in healthy aging and resilience, rather than a quick stimulant or temporary boost.
